Wollesen Lambert (avenuecycle1)

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.AIM The aim of this paper is to analyze hospital admission and associated factors following presentation to healthcare facilities for low back pain (LBP) in Ethiopia. METHODS A population-based cross-sectional study was conducted between June and November 2018 in South-west Shewa zone of Oromia regional state. Data were collected by face-to-face interviews of adults (≥18 years) with self-reported LBP using a newly developed and validated instrument. All the statistical analyses of (n = 543) individuals with a 1-year history of presentation to healthcare facilities for LBP were performed using R version 3.5.1. The log-binomial regression model was fitted and prevalence ratios with 95% confidence intervals (CIs) were calculated to identify factors associated with hospitalization and the significance level was considered at the P value of ≤ .05. RESULTS The proportion of hospital admissions following presentation to healthcare facilities for LBP was 14.4%, 95% CI 11.4-17.3, with an average length of stay (LOS) 7.4 days, 95% CI 6.4-8.8. The admission rate was 18.5%, 95% CI 13.4-23.3 in females and 11.4%, 95% CI 8.0-15.1 in males. Multiple factors, such as gender, age, living conditions, residential environment, alcohol consumption status, intensity of pain, and presence of additional spinal pain, were found to be independently associated with hospitalization for LBP. CONCLUSIONS The burden on the individuals and the Ethiopian healthcare system as a result of LBP is evident by the rate of hospital admissions. Further evidence on LBP case referral procedures is needed to allow health policy makers to develop appropriate management strategies capable of dealing with the increasing epidemiology of LBP. © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.SCOPE Maca (Lepidium meyenii), a well-known plant from the Andean highlands of Peru, has been used widely as a nutritional supplement to increase sexual function and fecundity. However, the identity of its active ingredients and how they function remain unknown. METHODS AND RESULTS Chemical substances in maca were identified by UPLC-Q-TOF, and the active ingredients were screened through HotMap coupled with an artificial neural network (ANN). Lepidiline A (LA), an imidazole alkaloid, was identified as the key active compound. LA affected the balance of endogenous sex hormones in mice and improved fecundity in Drosophila. Using a molecular LA probe, HSD17B1 was revealed to be the potential target of LA using a fishing-rod strategy. We demonstrated with experimental data that LA targets HSD17B1 to enhance the enzyme's activity and increase its bioconversion efficiency of actively formed sex hormones including estrogen to 17β-estradiol and 4-androsten-3,7-dione to testosterone which ultimately improved reproductive activity. CONCLUSION LA improved the balance of endogenous sex hormones and increased fecundity by targeting HSD17B1. This underlying mechanism of action provides a useful insight into the application of maca in the regulation of dietary nutrition and healthy fertility. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.A 32-year-old woman underwent radiofrequency catheter ablation of narrow QRS tachycardia that was terminated with intravenous adenosine. © 2020 Wiley Periodicals, Inc.The use of tourniquet during total knee arthroplasty (TKA) can result in ischaemia/reperfusion injury (IRI). Of interest, microRNAs (miRs) are reported to be involved in various kinds of IRI due to their ability in modulating autophagy. Therefore, the study aimed to investigate the effect of miR-153-3p on autophagy in IRI in vitro and in vivo under sevoflurane preconditioning. In the in vitro model, chondrocytes from naive mice were treated with 0% FBS alone or in combination with sevoflurane. se