Wright White (authorwound3)

HCA was obtained at concentrations ranging from 0.4 to 4 mg/ml and consisted of >90% IgG monomers. The mAb specifically reacted with a glycan epitope on CD52g, a glycoprotein produced in the male reproductive tract and found in abundance on sperm. HCA potently agglutinated sperm under a variety of relevant physiological conditions at concentrations ≥6.25 µg/ml, and mediated complement-dependent sperm immobilization at concentrations ≥1 µg/ml. HCA and its immune complexes did not induce inflammation in EpiVaginal™ tissue. HCA, an IgG1 mAb with potent sperm agglutination and immobilization activity and a good safety profile, is a promising candidate for female contraception. This research was supported by grants R01 HD095630 and P50HD096957 from the National Institutes of Health. This research was supported by grants R01 HD095630 and P50HD096957 from the National Institutes of Health.This study explores the key variables that influence overall waste minimization behaviors of consumers by augmenting the theory of planned behavior (TPB) with additional variables, including environmental concern, perceived consumer effectiveness, and perceived lack of facilities. Further, subjective norm is replaced by injunctive norm and descriptive norm. A questionnaire was administered to 455 consumers from North America, a region that faces acute waste production challenges. The findings suggest that perceived consumer effectiveness (PCE) constitutes the most influential variable to predict zero waste behavior (ZWB) intentions (β = 0.380 p less then 0.001), even surpassing perceived behavioral control (PBC) (β = 0.232 p less then 0.001), PBC also directly influences ZWB (β = 0.321 p less then 0.001), and injunctive norms (β = 0.171 p less then 0.05) exert a slightly greater influence than attitudes (β = 0.122 p less then 0.001). Importantly, environmental concern is a meaningful antecedent to all belief variables (i.e., control belief [β = 0.689 p less then 0.001], normative belief [β = 0.378 p less then 0.001], and behavioral belief [β = 0.367p less then 0.001]) while exerting an indirect effect on ZWB (β = 0.474 [0.299, 0.523]), especially via attitudes and PBC. Albeit perceived lack of facilities negatively impacts intentions (β = -0.073 p less then 0.05), it positively relates ZWB (β = 0.189 p less then 0.001) or worsens the effect of intentions on ZWB (β = -0.033 [-0.102, 0.036]). The results deliver crucial insights to devise impactful strategies and formulate sound policies to nudge consumers' ZWB. Our objective was to determine proportions, causes, and predictors of 30-day readmissions among older adults with epilepsy. Understanding predictors of readmissions may inform future interventions aimed at reducing avoidable hospitalizations in this vulnerable population. Individuals 65 years or older with epilepsy were identified using previously validated ICD-9-CM codes in any diagnostic position in the 2014 Nationwide Readmissions Database. Proportions of 30-day readmissions and causes of readmissions in older adults with epilepsy were compared to both older adults without and younger adults (18-64 years old) with epilepsy. We identified predictors of readmission in older adults with epilepsy using logistic regression. There were 92,030 older adults with, 3,166,852 older adults without, and 168,622 younger adults with epilepsy. Proportions of readmissions were higher in older adults with (16.2%) than older adults without (12.5%) and younger adults with epilepsy (15.1%). The main cause of readmission r findings suggest that targeted interventions to reduce the risk of infection may potentially reduce readmission in older people with epilepsy, similarly to those without. Provision of coordinated care and appropriate discharge planning may reduce readmissions particularly in those who are males, are of lower socioeconomic status and with more comorbidities. Although ketogeni