Laugesen Currin (armysquid5)

We investigate the effects of an increase in the production of secondary electrons when a β-source commonly used in internal radionuclide therapy,67Cu, is radiolabelled to a Super-Paramagnetic Iron Oxide Nanoparticle (SPION), with specific emphasis on the role of SPION cluster size and geometry. A positive relationship is found between the degree to which the nanoparticles are clustered and the associated radio-enhancement effects, with cluster population size playing a major role, as well as SPION separation within a cluster and the distance between clusters. Our simulation results indicate that SPIONs labelled with67Cu can induce a nonlinear amplification in the number of secondary electrons produced of up to 4% in bulk, with localised regions of nearer inter-SPION separation producing an increase of over 400% for a 20 nm average SPION separation. Such variation in enhancement due to local concentration effects may help identify clinical strategies that enhance efficacy for a given radiation dosage, or achieve equal efficacy with reduced radiation dosage. © 2020 Institute of Physics and Engineering in Medicine.We reveal early stages of self-organization of nanopatterns created by 2 keV Cs+ion-beam irradiation of a Si surface coated with Au and a Ti adhesion layer. After ion-beam etching of the metallic layers, at normal incidence, we first observe distinct transient stages (I) a dewetting-like pattern of grooves in the Si amorphized layer, sparsely populated with holes, followed by (II) the coexistence of rounded mounds and faceted holes distributed on a flat surface, the latter being an indication of the decisive role played by the crystalline/amorphous interface. Subsequently, the system evolves to stage III, a nanopattern of densely packed nanodots convoluted with a long-wavelength surface corrugation. A momentum-space analysis shows that stages (I) and (II) are identified, respectively, with channel-type and sphere-type quasi order. © 2020 IOP Publishing Ltd.Bimetallic Ag and Cu (11 wt %) NPs were synthesized and annealed at various temperatures from 400, 600 and 800 ˚C using chemical reduction techniques. High temperature annealed (800˚C) AgCu sample ratios (5 and 10 wt %) were used as dopant to MoS2. A variety of characterizations were employed to evaluate annealed and doped samples. XRD technique revealed that synthesized samples constitute FCC phase, and a gradual decrease in crystallite size corresponds to improved crystallinity upon heating and doping onto MoS2. FTIR was used for confirmation of functional groups in the products. The particle sizes of heated samples were less than 50 nm and presence of nanosheets in the doped MoS2 were confirmed using FESEM and TEM analysis. An increase in absorption was observed in bimetallic with increasing temperatures while band gap energy decreased. The vibrational property of bimetallic and doped MoS2 atomic layers was studied using Raman. Antimicrobial activity of prepared products was tested on MRSA-superbug with ciprofloxacin antibiotic as reference drug. Furthermore, molecular docking studies employed to unveil the binding interaction pattern of nanoparticle into the active pocket of β-lactamase enzyme suggested it to be a potential inhibitor that can be further evaluated for its enzyme inhibition characteristics. © 2020 IOP Publishing Ltd.Owing to the fascinating properties of two dimensional transition metal dichalcogenides and stability of ZIF-8 as the subclass of metal organic frameworks (MOFs), we propose a Mo-based MOFs material C48S36Mo6containing organic ligands [C16S12]8-connecting to each other by Mo4+metal ions. We reveal heavy-fermion-like electronic behaviour that results from highly localized impurity-like Mo-d electrons and tiny energy difference ( less then 0.4 meV/atom) between antiferromagnetic and ferromagnetic state, using the generalized gradient approximation and its combination with Coulomb correlation U. Considering thermal fluctuation and weak m