Mose Lemming (actionkite18)
The estimated prevalence for Brazil is 18%, however, it is suggested that this number is higher due to underreporting and the presence of asymptomatic cases. Therefore, new epidemiological studies are recommended throughout Brazil, to elucidate the profile of this disease in the country, in addition to assisting in the elaboration of an appropriate prevention plan by state. Data found in the literature regarding the epidemiological profile of VVC in Brazil are obsolete and incomplete, so the present systematic review has the proposal to analyze and identify the evidence on VVC prevalence in Brazil. The estimated prevalence is 18%, however, this number can be higher. Data found in the literature regarding the epidemiological profile of VVC in Brazil are obsolete and incomplete, so the present systematic review has the proposal to analyze and identify the evidence on VVC prevalence in Brazil. The estimated prevalence is 18%, however, this number can be higher.Pyrethroid insecticides have been widely utilized for insect pest control. Target-site resistance is one of the major mechanisms explaining pest resistance to pyrethroids. This study quantified pyrethroid resistance and fitness cost conferred by the voltage-gated sodium channel (VGSC) M918L mutation in Rhopalosiphum padi. Six s-kdr-SS and six s-kdr-RS parthenogenetic lineages were established from the same field population and were reared in the laboratory without exposure to pesticides for more than one year. Enzyme activity analysis demonstrated that metabolic resistance had no impact on these lineages. Bioassays showed that the M918L mutation strongly affected pyrethroid efficiency, conferring moderate resistance to bifenthrin (type I) (39.0-fold) and high resistance to lambda-cyhalothrin (type II) (194.7-fold). Compared with the life table of s-kdr-SS lineages, s-kdr-RS lineages exhibited a relative fitness cost with significant decreases in longevity and fecundity. Meanwhile, competitive fitness was measured by blending various ratios of s-kdr-SS and s-kdr-SS aphids. The results indicated that M918L-mediated resistance showed a significant fitness cost in the presence of wild aphids without insecticide pressure. The fitness cost strongly correlated with the initial resistance allele frequency. This work characterized the novel s-kdr M918L mutation in R. padi, defined its function in resistance to different types of pyrethroids, and documented that the M918L-mediated resistance has a significant fitness cost. The proliferation of social media in Plastic Surgery has posed significant difficulties for the public in determining legitimacy of information. In this work, we propose a system based on social network analysis (SNA) to assess the legitimacy of contributors of information within a Plastic Surgery community using academic Plastic Surgery and one social media outlet as a model. The aim of this study was to quantify the centrality of individual or group accounts on Plastic Surgery social media. To develop the model, we chose one high-fidelity, active, and legitimate source account in academic Plastic Surgery (@psrc1955, the Plastic Surgery Research Council) on one social media outlet (Instagram, Facebook, Menlo Park, CA, USA). Apoptosis inhibitor We then recorded all follower-following relationships between accounts and used Gephi (https//gephi.org/) to compute five different centrality metrics for each contributor within the network. We identified 64,737 unique users and 116,439 unique follower-followed relationships within the academic Plastic Surgery community. Among the metrics assessed, the in-degree centrality metric is the gold standard for SNA, hence we designated this metric as the Centrality Factor (CF). Stratification of 1000 accounts by CF demonstrated that all of the top 40 accounts were affiliated with a Plastic Surgery residency program, a board-certified academic plastic surgeon, a professional